| Expression pattern: |
UP |
| Associated gene: |
FOXP4 |
| Associated microRNA: |
miR-1182 |
| Biological function: |
promotes prostate cancer cell proliferation, cell-cycle progression, migration, invasion, and tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circABCC4 sponges miR-1182 to promote FOXP4 expression |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
high circABCC4 expression is associated with a poor prognosis and shorter 5-year survival rates; correlated with advanced stage and metastasis |
| Description: |
circABCC4 is up-regulated in prostate cancer and acts as an oncogenic circRNA. It functions as a ceRNA by sponging miR-1182, thereby relieving repression of FOXP4 and promoting proliferation, cell-cycle progression, migration, invasion, and xenograft tumor growth. High circABCC4 expression is associated with shorter survival and more advanced/metastatic disease. |
| Confidence score: |
0.7373 |