| Expression pattern: |
UP |
| Associated gene: |
ZNFX1 |
| Associated microRNA: |
has-miR-185-3p |
| Biological function: |
May be involved in the process and different pathogeneses of asthma; correlated with lung function and inflammatory indexes; potential biomarker for asthma diagnosis. |
| Molecular mechanism: |
Possible ceRNA regulatory network in which has_circSORT1 negatively correlates with has-miR-185-3p and positively correlates with ZNFX1, suggesting has_circSORT1/has-miR-185-3p/ZNFX1 may exist in asthma airway epithelium. |
| Biological pathway or process: |
ceRNA regulation (promotes); immune regulation (other); inflammation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for asthma diagnosis; AUC was 0.6739 with reported specificity 70.00% and sensitivity 69.12% at the cutoff. |
| Description: |
has_circSORT1 was significantly up-regulated in induced sputum cells from asthma patients and correlated with lung function and inflammatory indicators. The study suggests a possible has_circSORT1/has-miR-185-3p/ZNFX1 ceRNA regulatory network in asthma airway epithelium and proposes has_circSORT1 as a potential diagnostic biomarker. |
| Confidence score: |
0.5047 |