circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: cSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): chr4:144464661-144465125:+
Genomic location(hg38): chr4:143543508-143543972:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissues; adjacent normal tissues
Cell lines:

HeLa; Ca-Ski; C-33A; SiHa; Ect1/E6E7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EGFR, ERK1, ERK2
Associated microRNA: miR-432
Biological function: promotes proliferation and invasion of cervical cancer cells
Molecular mechanism: Acts as a miRNA sponge for miR-432 to modulate EGFR and activate ERK1/2 signaling
Biological pathway or process:

ERK (promotes); proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; MTT; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

cSMARCA5 is up-regulated in cervical cancer tissues and cell lines and promotes proliferation and invasion. Mechanistically, it functions as a sponge for miR-432, thereby relieving miR-432-mediated repression of EGFR and enhancing ERK1/2 signaling.
Confidence score:

0.7129
Other information
Title:

Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA‑432 sponge.

Journal: Molecular medicine reports
Published: 2020
PubMed ID: 31922210
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -