| Expression pattern: |
DN |
| Associated gene: |
Smad4, TGF-beta |
| Associated microRNA: |
miR-558 |
| Biological function: |
Inhibits proliferation, migration, and invasion; suppresses tumor growth and lung metastasis; inhibits EMT in OSCC. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-558, thereby relieving repression on Smad4 and modulating TGF-beta signaling to affect EMT. |
| Biological pathway or process: |
TGF-beta/SMAD (inhibits); EMT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circLDLRAD3 expression could distinguish OSCC and normal tissues (AUC = 0.783) and was negatively associated with lymphatic metastasis and TNM stages. |
| Description: |
circLDLRAD3 is downregulated in OSCC and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-558 to increase Smad4, thereby inhibiting TGF-beta-driven EMT and suppressing proliferation, migration, invasion, and metastasis. |
| Confidence score: |
0.8684 |