circRNA basic information
circBase ID: hsa_circ_0070661
Name: hsa_circ_CCDC109B
Synonym: -
Host Gene: CCDC109B
Genomic location(hg19): chr4:110580166-110608872:+
Genomic location(hg38): chr4:109659010-109687716:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissue; corresponding paracancerous tissue; LUAD tumors; adjacent normal tissue
Cell lines:

H1650; A549; PC9; BEAS-2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: TEK, Ago2
Associated microRNA: miR-556-5p
Biological function: Inhibits LUAD cell viability, migration, proliferation and tumor growth, and promotes apoptosis; acts as a tumor suppressor in LUAD.
Molecular mechanism: Hsa_circ_0070661 functions as a ceRNA by sponging miR-556-5p to release/upregulate TEK, thereby inhibiting LUAD progression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Provides a promising molecular target for LUAD clinical therapy and valued biomarkers for LUAD diagnosis.
Description:

Hsa_circ_0070661 is down-regulated in LUAD tissues and cell lines and mainly localized in the cytoplasm. Its overexpression suppresses LUAD cell proliferation/viability, migration and xenograft tumor growth while promoting apoptosis. Mechanistically, it sponges miR-556-5p to relieve repression of TEK, supporting its role as a tumor-suppressive circRNA and potential therapeutic target.
Confidence score:

0.7785
Other information
Title:

Hsa_circ_0070661 inhibits cancer progression through miR-556-5p/TEK axis in lung adenocarcinoma.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2023
PubMed ID: 37005879
Study type:

combined biological and clinical study
Data availability: This article contains all of the data that were created or examined during this investigation.
Code availability: -