| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-4482-3p, hsa-miR-146a-3p |
| Biological function: |
Potential serum diagnostic biomarker for NSCLC; higher serum levels were associated with more aggressive NSCLC features including lymph node metastasis, distant metastasis, and higher stage. |
| Molecular mechanism: |
Predicted circRNA-miRNA ceRNA-related regulatory network; the underlying mechanism was not experimentally elucidated. |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0008167 discriminated benign lung tumor from NSCLC with AUC 0.811, and higher serum levels were associated with LUSC subtype, lymph node metastasis, distant metastasis, and higher stage. |
| Description: |
hsa_circ_0008167 was up-regulated in serum from NSCLC patients and showed diagnostic value for distinguishing NSCLC from benign lung tumor. Its higher serum level was associated with more malignant clinical features, including lymph node metastasis, distant metastasis, and higher tumor stage, and it was incorporated into a predicted circRNA-miRNA diagnostic network with hsa-miR-4482-3p and hsa-miR-146a-3p. |
| Confidence score: |
0.459 |