| Expression pattern: |
UP |
| Associated gene: |
MSI1, Ago2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes CRC cell proliferation, cell cycle progression, colony formation, viability, migration, invasion, EMT and tumor growth, and suppresses apoptosis. |
| Molecular mechanism: |
Exosomal circ_FMN2 functions as a miR-338-3p sponge to upregulate MSI1, thereby promoting CRC progression. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Exosomal circ_FMN2 might be a target for CRC treatment. |
| Description: |
Serum exosomal circ_FMN2 is upregulated in CRC patients and CRC cells. It promotes CRC proliferation, metastasis, EMT and tumor growth while inhibiting apoptosis, mainly by sponging miR-338-3p and upregulating MSI1. The study suggests exosomal circ_FMN2 as a potential therapeutic target for CRC. |
| Confidence score: |
0.8006 |