| Expression pattern: |
UP |
| Associated gene: |
EGFR, Akt |
| Associated microRNA: |
miR-7 |
| Biological function: |
Promotes ccRCC cell proliferation and invasion. |
| Molecular mechanism: |
May promote ccRCC progression by activating the EGFR/Akt signaling pathway; ciRS-7 silencing decreases p-EGFR and p-Akt. |
| Biological pathway or process: |
EGFR (promotes); PI3K/AKT (promotes); proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
High ciRS-7 expression is associated with tumor diameter, clinical stage, distant metastasis, and shorter progression-free survival. |
| Description: |
ciRS-7 is up-regulated in ccRCC tissues and cell lines and promotes ccRCC cell proliferation and invasion. Mechanistically, ciRS-7 knockdown reduces p-EGFR and p-Akt, suggesting activation of the EGFR/Akt pathway. High ciRS-7 expression correlates with advanced clinicopathological features and shorter progression-free survival. |
| Confidence score: |
0.6148 |