| Expression pattern: |
DN |
| Associated gene: |
TNF |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker for AMI diagnosis; expression level is negatively correlated with AMI severity and may help identify high-risk AMI patients with large myocardial infarction area and severe coronary artery lesions. |
| Molecular mechanism: |
Bioinformatics prediction suggested that cSMARCA5 may participate in AMI by regulating TNF gene expression, with predicted downstream target miRNAs and mRNAs. |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
cSMARCA5 showed diagnostic ability for AMI with AUC 0.83, sensitivity 89.0%, and specificity 67.7%; its expression correlated with myocardial injury markers, LVEF, SYNTAX score, and GRACE risk score. |
| Description: |
cSMARCA5 (hsa_circ_0001445), derived from SMARCA5, is significantly down-regulated in the peripheral blood of AMI patients. Its lower expression is associated with greater myocardial injury and higher severity scores, and it shows potential diagnostic value for AMI. Bioinformatics analysis suggests that cSMARCA5 may participate in AMI through a predicted miRNA-mRNA regulatory network involving TNF. |
| Confidence score: |
0.459 |