| Expression pattern: |
UN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
participates in intercellular communication (release via EVs/RNPs and uptake by recipient cells) |
| Molecular mechanism: |
packaged and released via extracellular vesicles (EVs) from cancer cells and via ribonucleoprotein (RNP) complexes from non-cancer cells; taken up by recipient cells |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; FISH / smFISH; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
This circLSD1 RNA (from KDM1A) is mainly cytoplasmic and can be exported into the extracellular space, with cancer cells packaging it in EVs while non-cancer cells release it in RNP-protected forms. Extracellular circLSD1 RNAs can be taken up by recipient lung cells, supporting a role in intercellular communication in the lung cancer microenvironment. |
| Confidence score: |
0.6091 |