circRNA basic information
circBase ID: hsa_circ_0020080
Name: hsa_circ_FAM160B1
Synonym: hsa_circRNA_100685
Host Gene: FAM160B1
Genomic location(hg19): chr10:116590610-116608496:+
Genomic location(hg38): chr10:114830851-114848737:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; normal breast tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AGO1, AGO2, EIF4A3, FMRP, HuR (ELAVL1), IGF2BP1, IGF2BP2, IGF2BP3, EWSR1, FUS, PTB
Associated microRNA: hsa-miR-149, hsa-miR-182, hsa-miR-383
Biological function: Predicted hub circRNA acting as a super sponge with multiple miRNA response elements and potential capability of gene expression regulation in breast cancer.
Molecular mechanism: Predicted ceRNA mechanism through miRNA sponging, with predicted RBP interactions and downstream miRNA-mRNA/PPI network analysis.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Suggested as a potential targetable therapeutic element for breast cancer.
Description:

hsa_circ_0020080 was identified as a down-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance.
Confidence score:

0.1768
Other information
Title:

Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms.

Journal: Interdisciplinary sciences, computational life sciences
Published: 2019
PubMed ID: 31187432
Study type:

bioinformatics study
Data availability: GSE101123; GSE65194; TCGA; Supplementary 1; Supplementary 2; Supplementary 3A; Supplementary 4D
Code availability: -