circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: circUBAP2
Host Gene: UBAP2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018881
MONDO name: myelodysplastic syndrome
Disease details: myelodysplastic neoplasms / MDS
Disease DO ID:
 0050908
Disease MeSH ID:
 -
Disease NCIt ID:
 C3247
Disease ICD11 ID:
 -
Disease OMIM ID:
 614286
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow CD34+ cells; bone marrow
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in MDS patients with U2AF1 mutations and confirmed as differentially expressed between U2AF1-mutated patients and healthy controls in an independent cohort.
Molecular mechanism: No circUBAP2-specific mechanism was experimentally defined; article suggests U2AF1 mutations may alter circRNA biogenesis during splicing.
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker and therapeutic target investigation in U2AF1-mutated MDS.
Description:

circUBAP2 was identified as one of seven circRNAs significantly upregulated in U2AF1-mutated MDS and also differentially expressed in an independent cohort. No circUBAP2-specific functional mechanism was tested.
Confidence score:

0.348
Other information
Title:

Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.

Journal: Leukemia
Published: 2023
PubMed ID: 36922625
Study type:

combined biological and clinical study
Data availability: GSE224576; GSE89834; restricted access patient and healthy control RNA sequencing data; Supplementary Table S7
Code availability: https://github.com/omiics/PPT_finder10