circRNA basic information
circBase ID: hsa_circ_0006801
Name: hsa_circ_RNF13
Synonym: circRNF13
Host Gene: RNF13
Genomic location(hg19): chr3:149613259-149639014:+
Genomic location(hg38): chr3:149895472-149921227:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005515
MONDO name: oral cavity cancer
Disease details: oral cancer
Disease DO ID:
 8618
Disease MeSH ID:
 -
Disease NCIt ID:
 C9314
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissue samples; adjacent noncancerous tissue samples; oral cancer tissues; adjacent normal tissues
Cell lines:

CAL-27; SCC-9; Scc-25; HOK; HEK293
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2BP1, ITGB1 mRNA
Associated microRNA: -
Biological function: promotes proliferation; promotes tumor growth; promotes migration; promotes cisplatin chemoresistance; inhibits apoptosis
Molecular mechanism: circRNF13 binds IGF2BP1 to inhibit its ubiquitination-mediated degradation and promote IGF2BP1 phase separation, thereby enhancing m6A-dependent stabilization of ITGB1 mRNA via IGF2BP1.
Biological pathway or process:

proliferation (promotes); migration (promotes); apoptosis (inhibits); chemoresistance (promotes); m6A modification (promotes); mRNA stability (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Co-IP; IF (Immunofluorescence); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; ISH (In Situ Hybridization); IHC (Immunohistochemistry); TUNEL; Microarray
Clinical significance:

circRNF13 is correlated with increased tumor grade and stage in oral cancer.
Description:

circRNF13 is up-regulated in oral cancer tissues/cell lines and promotes proliferation, migration, tumor growth and cisplatin chemoresistance. Mechanistically, it binds the m6A reader RBP IGF2BP1 to inhibit ubiquitination-mediated degradation and enhance IGF2BP1 phase separation, which increases m6A-dependent stabilization of ITGB1 mRNA.
Confidence score:

0.8585
Other information
Title:

CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance.

Journal: Molecular cancer
Published: 2025
PubMed ID: 39891203
Study type:

combined biological and clinical study
Data availability: GSE131182; GSE131568
Code availability: -