circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circZNF609
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018881
MONDO name: myelodysplastic syndrome
Disease details: myelodysplastic neoplasms / MDS
Disease DO ID:
 0050908
Disease MeSH ID:
 -
Disease NCIt ID:
 C3247
Disease ICD11 ID:
 -
Disease OMIM ID:
 614286
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow CD34+ cells; bone marrow
Cell lines:

K562
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in MDS patients with U2AF1 mutations; knockdown had less marked effects, with only one gene significantly upregulated.
Molecular mechanism: Predicted miRNA interaction analysis was performed, but no specific validated mechanism was established for circZNF609 in U2AF1-mutated MDS.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; Bioinformatics Analysis; Transfection; RT-qPCR
Clinical significance:

Potential biomarker and therapeutic target investigation in U2AF1-mutated MDS.
Description:

circZNF609 was upregulated in MDS patients with U2AF1 mutations and selected for knockdown because it was highly expressed in U2AF1-mutated K562 clones and previously described in cancer. Its knockdown had limited transcriptional effects compared with circCSNK1G3 and circMAN1A2.
Confidence score:

0.4997
Other information
Title:

Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.

Journal: Leukemia
Published: 2023
PubMed ID: 36922625
Study type:

combined biological and clinical study
Data availability: GSE224576; GSE89834; restricted access patient and healthy control RNA sequencing data; Supplementary Table S7
Code availability: https://github.com/omiics/PPT_finder10