| Expression pattern: |
DN |
| Associated gene: |
DKK1, Wnt/b-catenin signaling pathway, Wnt/beta-catenin signaling pathway |
| Associated microRNA: |
miR-6783-3p |
| Biological function: |
Acts as a tumor suppressor in LUAD; overexpression suppresses cell proliferation, migration, invasion, EMT progress, and tumor growth in vivo. |
| Molecular mechanism: |
circ_0006427 functions as a miRNA sponge for miR-6783e3p/miR-6783-3p, positively regulates DKK1, and inactivates Wnt/b-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; circRIP; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low expression of circ_0006427 predicted poor prognosis in LUAD patients and was correlated with TNM stage, tumor size and lymph node metastasis. |
| Description: |
circ_0006427 is down-regulated in LUAD tissues and cell lines, and low expression is associated with advanced disease features and poor prognosis. Functionally, circ_0006427 acts as a tumor suppressor by inhibiting LUAD cell proliferation, migration, invasion, EMT, and in vivo tumor growth. Mechanistically, cytoplasmic circ_0006427 sponges miR-6783e3p/miR-6783-3p to upregulate DKK1 and thereby inactivate the Wnt/beta-catenin signaling pathway. |
| Confidence score: |
0.8657 |