circRNA basic information
circBase ID: hsa_circ_0006089
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:9490936-9499018:+
Genomic location(hg38): chr2:9350807-9358889:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FNDC1
Associated microRNA: hsa-miR-32-3p
Biological function: May impact the onset, progression, and prognosis of gastric cancer by competitively sponging hsa-miR-32-3p to regulate FNDC1 expression.
Molecular mechanism: ceRNA sponge mechanism (competitive sponging of hsa-miR-32-3p to modulate FNDC1).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Prognosis-related ceRNA network identified for gastric cancer.
Description:

This study proposed hsa_circ_0006089 as part of a FNDC1 prognostic ceRNA axis in gastric cancer via sponging hsa-miR-32-3p. The work is computational, relying on GEO differential expression and ceRNA network construction with TCGA survival integration.
Confidence score:

0.1768
Other information
Title:

CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.

Journal: Discover oncology
Published: 2025
PubMed ID: 41417426
Study type:

bioinformatics study
Data availability: TCGA-STAD; GSE83521; GSE93415; GSE118916; https://www.proteinatlas.org
Code availability: -