| Expression pattern: |
UP |
| Associated gene: |
IGFBP5 |
| Associated microRNA: |
miR-1224-5p |
| Biological function: |
Promotes KD-derived fibroblast proliferation, cell cycle progression, migration, invasion and ECM-related protein expression, and represses apoptosis. |
| Molecular mechanism: |
Circ_0008450 acts as a miR-1224-5p sponge to increase IGFBP5 expression, thereby regulating KD-derived fibroblast phenotypes. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); fibrosis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
The study suggests the potential of targeting circ_0008450/miR-1224-5p/IGFBP5 axis to combat KD. |
| Description: |
Circ_0008450 is up-regulated in keloid tissues and keloid-derived fibroblasts and mainly localizes to the cytoplasm. It promotes fibroblast proliferation, cell cycle progression, migration, invasion and ECM marker expression while inhibiting apoptosis. Mechanistically, circ_0008450 sponges miR-1224-5p to increase IGFBP5 expression, forming a circ_0008450/miR-1224-5p/IGFBP5 regulatory axis with potential therapeutic relevance in keloid. |
| Confidence score: |
0.7799 |