| Expression pattern: |
UP |
| Associated gene: |
SOX2 |
| Associated microRNA: |
miR-429 |
| Biological function: |
Hsa_circ_0084912 promotes cervical cancer cell proliferation, colony formation, migration, and tumor growth in vivo; knockdown suppresses malignant phenotypes. |
| Molecular mechanism: |
Hsa_circ_0084912 acts as a ceRNA that sponges miR-429 and increases SOX2 expression, thereby promoting cervical cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Hsa_circ_0084912 is proposed as a viable and promising target for cervical cancer treatment. |
| Description: |
Hsa_circ_0084912 is upregulated in cervical cancer tissues and cells. It promotes cervical cancer progression by sponging miR-429 to increase SOX2 expression, thereby enhancing proliferation, colony formation, migration, and xenograft tumor growth. The study proposes hsa_circ_0084912 as a potential therapeutic target for cervical cancer. |
| Confidence score: |
0.7795 |