| Expression pattern: |
UP |
| Associated gene: |
LASP1, Ago2 |
| Associated microRNA: |
miR-944 |
| Biological function: |
Circ_0072088 promotes CDDP resistance and CDDP-resistant NSCLC cell malignancy, including proliferation, colony formation, migration, and invasion, while inhibiting apoptosis; circ_0072088 knockdown improves CDDP sensitivity and represses tumor progression in vitro and in vivo. |
| Molecular mechanism: |
Circ_0072088 acts as a ceRNA by sponging miR-944, thereby upregulating LASP1 expression and regulating CDDP sensitivity and tumor progression in CDDP-resistant NSCLC. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ_0072088 expression was significantly associated with tumor-node-metastasis stage and tumor size; the findings support the utility of circ_0072088 as a diagnostic marker for NSCLC. |
| Description: |
Circ_0072088 is upregulated in CDDP-resistant NSCLC tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-944 and increasing LASP1 expression, while circ_0072088 knockdown enhances CDDP sensitivity and suppresses tumor progression in vitro and in vivo. |
| Confidence score: |
0.78 |