| Expression pattern: |
UP |
| Associated gene: |
ADAM10 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
circ_0000595 promotes CoCl2-mediated VSMC dysfunction by suppressing VSMC proliferation and promoting VSMC apoptosis; circ_0000595 knockdown restores proliferation and reduces apoptosis. |
| Molecular mechanism: |
circ_0000595 functions as a ceRNA that sponges miR-582-3p to increase ADAM10 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
relative serum circ_0000595 levels were positively associated with aortic diameter change in TAA patients; circ_0000595 may provide a potential therapeutic target for TAA. |
| Description: |
circ_0000595 is upregulated in TAA aortic tissues and CoCl2-induced hypoxic VSMCs. It acts as a ceRNA sponge for miR-582-3p to promote ADAM10 expression, thereby suppressing VSMC proliferation and promoting apoptosis; circ_0000595 knockdown alleviates these CoCl2-mediated effects. |
| Confidence score: |
0.8111 |