| Expression pattern: |
UP |
| Associated gene: |
SPI1, EIF4A3, IL6, JAK2, STAT3 |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell viability, proliferation, invasion, migration, and in vivo tumor growth; associated with diagnosis and poor prognosis. |
| Molecular mechanism: |
circABCA5 binds SPI1 protein, upregulates SPI1 expression and promotes SPI1 nuclear translocation; SPI1 transcriptionally upregulates IL6 and activates IL6/JAK2/STAT3 signaling; EIF4A3 binds circABCA5 and promotes its stability and expression. |
| Biological pathway or process: |
JAK/STAT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; IF (Immunofluorescence); Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; ChIP / ChIP-seq; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; ELISA; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circABCA5 expression is correlated with progression and poor prognosis; circABCA5 may serve as a marker for diagnosis and prognosis evaluation and as a molecular target for treatment. |
| Description: |
circABCA5/hsa_circ_0107595 is upregulated in gastric cancer tissues and high expression is associated with shorter patient survival. Functionally, circABCA5 promotes gastric cancer cell proliferation, invasion, migration, and xenograft growth. Mechanistically, EIF4A3 stabilizes circABCA5, while circABCA5 binds and upregulates SPI1, promoting SPI1 nuclear translocation and activation of IL6/JAK2/STAT3 signaling. |
| Confidence score: |
0.8967 |