| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-139-3p, miR-200, miR-367-3p, miR-33a-3p |
| Biological function: |
promotes cell proliferation and cell cycle progression, inhibits apoptosis, and promotes cell migration in gastric cancer cells |
| Molecular mechanism: |
may function as a miRNA sponge (ceRNA) interacting with multiple miRNAs |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Bioinformatics Analysis |
| Clinical significance: |
may be considered as a potential biomarker for use in diagnosing gastric carcinoma |
| Description: |
hsa_circ_0000592 is up-regulated in MNNG-induced malignant-transformed gastric epithelial cells and multiple gastric cancer cell lines. Its knockdown suppresses proliferation, induces G0/G1 arrest, increases apoptosis, and reduces migration, and it is mainly cytoplasmic, suggesting a potential ceRNA/miRNA-sponging role and possible diagnostic biomarker potential in gastric carcinoma. |
| Confidence score: |
0.6157 |