circRNA basic information
circBase ID: hsa_circ_0067934
Name: hsa_circ_PRKCI
Synonym: circ_0067934
Host Gene: PRKCI
Genomic location(hg19): chr3:170013698-170015181:+
Genomic location(hg38): chr3:170295910-170297393:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent normal tissues; xenograft tissues
Cell lines:

16HBE; H358; H23
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: KLF8, Ago2
Associated microRNA: miR-1182
Biological function: Promotes NSCLC cell proliferation, migration, invasion, EMT and tumor growth, and inhibits apoptosis.
Molecular mechanism: Circ_0067934 functions as a ceRNA by sponging miR-1182, regulating KLF8, and activating the Wnt/beta-catenin pathway.
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for NSCLC.
Description:

Circ_0067934 is up-regulated in NSCLC tissues and cells. It promotes NSCLC progression by acting as a ceRNA for miR-1182, thereby regulating KLF8 and activating the Wnt/beta-catenin pathway. Silencing circ_0067934 inhibits proliferation, migration, invasion, EMT and tumor growth, while inducing apoptosis.
Confidence score:

0.7289
Other information
Title:

Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2020
PubMed ID: 32768951
Study type:

combined biological and clinical study
Data availability: Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.biopha.2020.110461.
Code availability: -