circRNA basic information
circBase ID: hsa_circ_0017884
Name: hsa_circ_VIM
Synonym: hsa-cVIM
Host Gene: VIM
Genomic location(hg19): chr10:17279228-17279592:+
Genomic location(hg38): chr10:17237229-17237593:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005155
MONDO name: cirrhosis of liver
Disease details: liver fibrosis
Disease DO ID:
 5082
Disease MeSH ID:
 D008103
Disease NCIt ID:
 C2951
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissues; sera
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TGFBR1, TGFBR2
Associated microRNA: miR-9-5p, miR-122-5p
Biological function: potential diagnostic biomarker for liver fibrosis in CHB patients
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study
Clinical significance:

serum hsa-cVIM differentiates CHB patients with liver fibrosis from healthy controls (AUC 0.895) and increases with fibrosis stage
Description:

In human CHB/CHC-related liver fibrosis, hsa_circ_0017884 (hsa-cVIM) is upregulated in liver tissue and serum. Serum hsa-cVIM shows diagnostic utility for liver fibrosis and correlates positively with fibrosis stage.
Confidence score:

0.4758
Other information
Title:

Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-beta signaling cascade.

Journal: Communications biology
Published: 2024
PubMed ID: 38243118
Study type:

clinical study
Data availability: Supplementary Data 1; Supplementary Fig. 12
Code availability: -