circRNA basic information
circBase ID: hsa_circ_0001715
Name: -
Synonym: circ_0001715
Host Gene: -
Genomic location(hg19): chr7:73521339-73523366:+
Genomic location(hg38): chr7:74107009-74109036:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; H1975; BEAS-2B; THP-1; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TREM2
Associated microRNA: miR-205-5p
Biological function: Promotes M2 macrophage polarization and promotes LUAD cell proliferation, migration, invasion/metastasis.
Molecular mechanism: Exosomal circ_0001715 acts as a miRNA sponge for miR-205-5p, thereby upregulating TREM2 to enhance M2 macrophage polarization and promote LUAD progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); macrophage polarization (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Flow Cytometry（Non-apoptosis/cycle）; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

In LUAD cell-macrophage coculture, tumor-derived exosomal circ_0001715 promotes M2 macrophage polarization and thereby enhances LUAD cell proliferation, migration, and invasion/metastasis. Mechanistically, circ_0001715 sponges miR-205-5p to de-repress/positively regulate TREM2, and TREM2 is required for the exosomal circ_0001715 effects.
Confidence score:

0.5634
Other information
Title:

Tumor-related exosomal circ_0001715 promotes lung adenocarcinoma cell proliferation and metastasis via enhancing M2 macrophage polarization by regulating triggering receptor expressed on myeloid cells-2.

Journal: Thoracic cancer
Published: 2024
PubMed ID: 38087801
Study type:

biological research
Data availability: The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -