| Expression pattern: |
DN |
| Associated gene: |
EPB41L5, RhoC, AKT, phospho-AKT |
| Associated microRNA: |
miR-19a |
| Biological function: |
Inhibits glioblastoma cell proliferation, colony formation, migration and invasion, and suppresses tumorigenesis in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-19a to relieve miR-19a-mediated repression of host gene EPB41L5, thereby inhibiting RhoC and p-AKT signaling. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); PI3K/AKT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
Low circ-EPB41L5 expression is associated with poor prognosis and is an independent prognostic factor for poor PFS and OS in glioblastoma patients. |
| Description: |
Circ-EPB41L5 is down-regulated in glioblastoma and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-19a, thereby increasing EPB41L5 expression and suppressing downstream RhoC and AKT phosphorylation, leading to reduced proliferation, migration, invasion, and tumorigenesis. Low circ-EPB41L5 levels are associated with worse patient survival. |
| Confidence score: |
0.8426 |