| Expression pattern: |
UP |
| Associated gene: |
MAPK1, Ago2 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
circCAMSAP1 promotes EC cell proliferation, migration and invasion, represses apoptosis, and is associated with malignant behavior; silencing circCAMSAP1 suppresses these malignant phenotypes and increases apoptosis. |
| Molecular mechanism: |
circCAMSAP1 acts through a ceRNA-like mechanism by targeting miR-370-3p and regulating MAPK1; silencing circCAMSAP1 increases miR-370-3p and decreases MAPK1-associated malignant effects. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Western Blot; Transwell Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
The circCAMSAP1/miR-370-3p/MAPK1 axis may become a new marker for EC diagnosis and treatment. |
| Description: |
circCAMSAP1 is up-regulated in endometrial cancer tissues and cell lines. It promotes malignant phenotypes of EC cells, including proliferation, migration and invasion, while inhibiting apoptosis, and functions through the miR-370-3p/MAPK1 regulatory axis. Silencing circCAMSAP1 suppresses EC cell malignant behavior and may provide a diagnostic or therapeutic marker axis. |
| Confidence score: |
0.7045 |