circRNA basic information
circBase ID: hsa_circ_0002346
Name: -
Synonym: hsa_-circ_0002346
Host Gene: -
Genomic location(hg19): chr2:36623756-36669878:+
Genomic location(hg38): chr2:36396613-36442735:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; matched adjacent non-cancerous tissues; tumor and adjacent normal tissues
Cell lines:

BT-549; MDA-MB-231; SKBR-3; MCF-7; BT-474; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Inhibits proliferation, colony formation, migration and invasion of breast cancer cells, promotes apoptosis, and may suppress EMT-associated metastatic processes.
Molecular mechanism: hsa_circ_0002346 may regulate breast cancer progression through EMT-related processes; knockdown increased EMT-associated proteins including vimentin, MMP-2 and MMP-9.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); metastasis (inhibits)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

hsa_circ_0002346 is correlated with lymph node metastasis and emerges as a promising biomarker for breast cancer and a potential therapeutic target.
Description:

hsa_circ_0002346 is downregulated in breast cancer tissues and cell lines. Functional knockdown experiments indicate that it acts as a tumor-suppressive circRNA by inhibiting proliferation, colony formation, migration, invasion and EMT-associated changes while promoting apoptosis. Clinically, its expression is associated with lymph node metastasis, suggesting biomarker potential.
Confidence score:

0.6599
Other information
Title:

Hsa_circ_0002346 inhibits proliferation, invasion, and migration of breast cancer cells and promotes apoptosis: A novel potential biomarker for breast cancer.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2024
PubMed ID: 40094400
Study type:

combined biological and clinical study
Data availability: -
Code availability: -