| Expression pattern: |
UP |
| Associated gene: |
NF-kappaB, PD-L1 |
| Associated microRNA: |
hsa-let-7b-5p, hsa-let-7c-5p |
| Biological function: |
May promote inflammatory response in PD through sponge effects on hsa-let-7b-5p and hsa-let-7c-5p; expression is elevated in PD and reduced after rehabilitation. |
| Molecular mechanism: |
Predicted ceRNA sponge mechanism involving hsa-let-7b-5p and hsa-let-7c-5p, inflammatory response, and possible NF-kappaB pathway activation. |
| Biological pathway or process: |
inflammation (promotes); NF-kappaB (promotes); ceRNA regulation (other); immune regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic target and rehabilitation-responsive biomarker for PD. |
| Description: |
hsa_circ_0000437/circCORO1C is up-regulated in peripheral blood exosomes from PD patients and decreases after rehabilitation. The study suggests that it may promote inflammatory responses in PD by sponging hsa-let-7b-5p and hsa-let-7c-5p and may be connected to NF-kappaB-related inflammatory signaling. |
| Confidence score: |
0.4032 |