| Expression pattern: |
UP |
| Associated gene: |
CCNB1, Ago2, RAD23B |
| Associated microRNA: |
miR-1205 |
| Biological function: |
Promotes breast cancer cell proliferation, clone formation, migration, tumor growth, and malignancy; circ_0137652 knockdown inhibits BC progression in vitro and in vivo. |
| Molecular mechanism: |
circ_0137652 functions as a ceRNA sponge for miR-1205 and regulates the downstream miR-1205/CCNB1 axis to promote breast cancer malignancy. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0137652 may provide a novel biomarker for BC diagnosis and therapy and may be a novel target for BC therapy. |
| Description: |
hsa_circ_0137652 is upregulated in breast cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes breast cancer malignancy by sponging miR-1205 and regulating the downstream CCNB1 axis, thereby enhancing proliferation, clone formation, migration, and xenograft tumor growth. The study suggests circ_0137652 may serve as a potential biomarker and therapeutic target for breast cancer. |
| Confidence score: |
0.7893 |