circRNA basic information
circBase ID: hsa_circ_0001461
Name: hsa_circ_ABCE1
Synonym: -
Host Gene: ABCE1
Genomic location(hg19): chr4:187627716-187630999:-
Genomic location(hg38): chr4:186706562-186709845:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissue; normal tissue; paracancer tissue
Cell lines:

LoVo; HCT116; SW480; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: ABCE1
Associated microRNA: -
Biological function: inhibits proliferation
Molecular mechanism: circRNA-miRNA-mRNA regulatory network (ceRNA-like) with concordant host gene association (ABCE1)
Biological pathway or process:

proliferation (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Transfection; EdU Staining
Clinical significance:

-
Description:

In CRC models, hsa_circ_0001461 functions as an anti-proliferative circRNA: siRNA-mediated silencing in LoVo cells decreased proliferation. The study also places it within a predicted circRNA-miRNA-mRNA regulatory network and reports concordant expression with its host gene ABCE1.
Confidence score:

0.6956
Other information
Title:

Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.

Journal: Clinical and translational medicine
Published: 2024
PubMed ID: 39397316
Study type:

combined biological and clinical study
Data availability: PRJCA019939; GSE161277; GSE221240; GSE235850
Code availability: https://github.com/wangjun‐bio/miRlab/tree/CRC