| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-124 |
| Biological function: |
circ_0000502 promotes HCC cell proliferation, invasion, migration and metastasis, and inhibits apoptosis; knockdown of circ_0000502 reduces proliferation, invasion and migration and promotes apoptosis. |
| Molecular mechanism: |
circ_0000502 promotes malignant progression of HCC by targeting, binding to and negatively regulating miR-124, consistent with a miRNA sponge/ceRNA-related mechanism. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circ_0000502 was significantly positively correlated with poor prognosis of HCC; high expression was associated with lower overall survival and worse prognosis. |
| Description: |
circ_0000502 is up-regulated in HCC tissues and cell lines and its high expression is associated with poor prognosis. Functionally, circ_0000502 promotes HCC proliferation, invasion, migration and metastasis while inhibiting apoptosis. Mechanistically, it directly targets and negatively regulates miR-124, and miR-124 can counteract the effects of circ_0000502 in HCC cells. |
| Confidence score: |
0.7078 |