circRNA basic information
circBase ID: hsa_circ_0000043
Name: hsa_circ_PUM1
Synonym: circPUM1
Host Gene: PUM1
Genomic location(hg19): chr1:31465236-31468067:-
Genomic location(hg38): chr1:30992389-30995220:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous gastric tissues; adjacent tumor-free gastric tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KRAS
Associated microRNA: has-miR-326
Biological function: accelerates GC cell proliferation and invasion
Molecular mechanism: ceRNA mechanism via has-miR-326 to positively regulate KRAS expression
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

might be served as promising biomarkers for GC diagnosis and targeted therapy
Description:

hsa_circ_0000043 (circPUM1) is up-regulated in gastric cancer tissues and is implicated in a ceRNA axis where it mediates has-miR-326 to positively regulate KRAS, contributing to increased proliferation and invasion in GC.
Confidence score:

0.4032
Other information
Title:

Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer.

Journal: International journal of genomics
Published: 2022
PubMed ID: 35685832
Study type:

combined biological and clinical study
Data availability: GSE152309; GSE121445; TCGA-STAD
Code availability: -