circRNA basic information
circBase ID: hsa_circ_0001361
Name: hsa_circ_FNDC3B
Synonym: circRNA_0001361
Host Gene: FNDC3B
Genomic location(hg19): chr3:171830241-171851336:+
Genomic location(hg38): chr3:172112451-172133546:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue samples; serum; peripheral blood samples
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: FGFR4
Associated microRNA: miR-491 / miR-491-5p
Biological function: Associated with axillary response to neoadjuvant chemotherapy; higher circRNA level relates to worse therapeutic outcome and promotes FGFR4 expression by sponging miR-491-5p.
Molecular mechanism: ceRNA mechanism: hsa_circ_0001361 sponges miR-491-5p, relieving repression on FGFR4 and increasing FGFR4 expression.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; IHC (Immunohistochemistry)
Clinical significance:

Low circRNA expression is associated with better outcome after NAC treatment.
Description:

In breast cancer patients receiving neoadjuvant chemotherapy, lower hsa_circ_0001361 expression is associated with better axillary response. Mechanistically, hsa_circ_0001361 acts as a sponge for miR-491-5p, leading to increased FGFR4 expression.
Confidence score:

0.6765
Other information
Title:

The circRNA-0001361/miR-491/FGFR4 axis is associated with axillary response evaluated by ultrasound following NAC in subjects with breast cancer.

Journal: Biochemistry and biophysics reports
Published: 2023
PubMed ID: 37250983
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -