| Expression pattern: |
UP |
| Associated gene: |
Keap1, Nrf2, NF-kappaB p65, RANKL, OPG, IL-1beta, IL-6, MDA, GSH |
| Associated microRNA: |
miR-1225-5p |
| Biological function: |
Associated with postmenopausal osteoporosis severity; promotes imbalance in bone homeostasis, oxidative stress, inflammatory signaling, and osteoclastogenesis-related markers. |
| Molecular mechanism: |
ceRNA mechanism involving circ-0091579 sponging miR-1225-5p, activation of the Keap1-Nrf2 cascade, enhanced ROS production, and augmentation of NF-kappaB expression and downstream cytokines. |
| Biological pathway or process: |
ceRNA regulation (promotes); NF-kappaB (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Western Blot; ELISA; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for early detection of osteoporosis and tracking its progression; circ-0091579 discriminated osteopenic and osteoporotic patients from controls and predicted progression of osteoporosis. |
| Description: |
circ-0091579 was upregulated in PBMCs from postmenopausal women with osteopenia and osteoporosis and increased with disease severity. The study suggests that circ-0091579 targets miR-1225-5p to regulate the Keap1-Nrf2 and NF-kappaB/inflammatory cytokine network, contributing to oxidative stress, bone homeostasis imbalance, and osteoporosis progression; it also showed diagnostic and progression-tracking biomarker potential. |
| Confidence score: |
0.6032 |