| Expression pattern: |
UP |
| Associated gene: |
HOXA7, QKI |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
promotes proliferation, invasion, and tumor growth in cervical cancer |
| Molecular mechanism: |
circSLC26A4 acts as a miRNA sponge for miR-1287-5p to regulate HOXA7; QKI binds QREs in flanking introns to promote circSLC26A4 biogenesis |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Actinomycin D / DRB Stability Assay; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high expression of circSLC26A4 was related to the poor survival of cervical cancer patients |
| Description: |
circSLC26A4 is upregulated in cervical cancer and promotes malignant phenotypes (proliferation, invasion, and xenograft tumor growth). It functions as a ceRNA by sponging miR-1287-5p to relieve repression of HOXA7, and its biogenesis is promoted by the RBP QKI via binding QREs in flanking introns. |
| Confidence score: |
0.8568 |