| Expression pattern: |
DN |
| Associated gene: |
TUBB2A |
| Associated microRNA: |
miR-421 |
| Biological function: |
Suppresses proliferation, migration, and invasion of gastric cancer cells and inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miR-421 sponge to upregulate TUBB2A, thereby suppressing gastric cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_C16orf62 is down-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It suppresses GC cell proliferation, migration and invasion and inhibits xenograft tumor growth by sponging miR-421 to increase TUBB2A expression. |
| Confidence score: |
0.7223 |