| Expression pattern: |
DN |
| Associated gene: |
SOCS3 |
| Associated microRNA: |
miR-221-3p |
| Biological function: |
circANKRD28 overexpression inhibits DDP resistance, proliferation, colony formation, invasion, migration and tumor growth, and promotes apoptosis in DDP-resistant NSCLC cells. |
| Molecular mechanism: |
circANKRD28 acts as a molecular sponge for miR-221-3p and regulates tumor cell progression and DDP sensitivity through the miR-221-3p/SOCS3 axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); chemoresistance (inhibits); drug resistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circANKRD28 had high diagnostic and prognostic values in NSCLC; its expression level was associated with DDP resistance, depth of invasion and differentiation. |
| Description: |
circANKRD28 is downregulated in NSCLC, especially in DDP-resistant tissues and cells. Its overexpression suppresses malignant phenotypes and cisplatin resistance by sponging miR-221-3p and relieving repression of SOCS3, thereby increasing DDP sensitivity in vitro and in vivo. |
| Confidence score: |
0.8571 |