| Expression pattern: |
UP |
| Associated gene: |
SMO |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes glioma cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circSMO742 acts as a miRNA sponge for miR-338-3p, thereby relieving miR-338-3p-mediated repression of SMO and increasing SMO expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Western Blot; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
- |
| Description: |
circSMO742 is up-regulated in glioma and mainly localizes to the cytoplasm. It promotes glioma cell proliferation, migration and invasion and inhibits apoptosis by sponging miR-338-3p, thereby increasing SMO expression; circSMO742 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8252 |