circRNA basic information
circBase ID: hsa_circ_0001522
Name: hsa_circ_CSNK1G3
Synonym: circ_0001522
Host Gene: CSNK1G3
Genomic location(hg19): chr5:122881110-122893258:+
Genomic location(hg38): chr5:123545416-123557564:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

FFPE tumor samples
Cell lines:

MDA-MB-231; BT-549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCND1, MMP1, AGO2, CPSF7, TARDBP, UPF1, LIN28B
Associated microRNA: miR-579-3p, miR-4458
Biological function: promotes TNBC cell proliferation, colony formation, 3D organoid/spheroid growth, and migration; supports cell viability and contributes to cell death resistance
Molecular mechanism: acts as a miRNA sponge and is predicted to bind RBPs; circRNA depletion alters miRNA and mRNA expression programs
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (other); metastasis (other); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; divergent primers PCR; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Transfection; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ_0001522 expression is associated with poor relapse-free survival (RFS) and predicts unfavorable prognosis.
Description:

circ_0001522 is upregulated in breast cancer/TNBC and high expression is linked to poor relapse-free survival. Its knockdown suppresses TNBC proliferation, colony formation, 3D growth and migration. Mechanistically, it is predicted to function via miRNA sponging (miR-579-3p, miR-4458) and potential RBP interactions, reshaping downstream mRNA programs (e.g., CCND1, MMP1).
Confidence score:

0.8182
Other information
Title:

Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks.

Journal: Cell death discovery
Published: 2025
PubMed ID: 40634303
Study type:

combined biological and clinical study
Data availability: PRJNA954402
Code availability: -