| Expression pattern: |
UP |
| Associated gene: |
RAD21 |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
CircROBO1 promotes HCC cell proliferation and radioresistance, inhibits apoptosis and radiosensitivity, and its knockdown enhances radiosensitivity in vitro and in vivo. |
| Molecular mechanism: |
CircROBO1 acts as a miR-136-5p sponge to positively regulate RAD21, thereby promoting HCC radioresistance. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Colony Formation Assay; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
High circROBO1 expression was associated with shorter overall survival, tumor size, TNM stage, and vascular invasion in HCC patients; circROBO1 may be a promising target for treating HCC radioresistance. |
| Description: |
CircROBO1 is up-regulated in HCC tissues, HCC cells, and especially IR-resistant HCC tumor tissues. It promotes HCC radioresistance by acting as a miR-136-5p sponge to up-regulate RAD21, thereby enhancing proliferation and suppressing apoptosis; knockdown of circROBO1 improves radiosensitivity in vitro and in a Huh7 xenograft model. Clinically, high circROBO1 expression is associated with poorer overall survival and aggressive clinicopathologic features. |
| Confidence score: |
0.798 |