| Expression pattern: |
UP |
| Associated gene: |
IGF2BP1, ZNF124, Bax, Bcl-2, MDR1, Ki67 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
Promotes cisplatin resistance, cell proliferation, migration, invasion and tumor growth; inhibits apoptosis and cisplatin sensitivity in DDP-resistant endometrial carcinoma cells. |
| Molecular mechanism: |
circ_0005667 acts as a ceRNA by sponging miR-145-5p to elevate IGF2BP1 expression, thereby enhancing DDP resistance and oncogenic behaviors in endometrial carcinoma cells. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0005667 was reinforced in DDP-resistant EC tissues and may provide a new targeted treatment strategy for EC, especially DDP resistance. |
| Description: |
circ_0005667 is up-regulated in cisplatin-resistant endometrial carcinoma tissues and cells. It promotes DDP resistance, proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly through the circ_0005667/miR-145-5p/IGF2BP1 regulatory axis. |
| Confidence score: |
0.8006 |