| Expression pattern: |
UP |
| Associated gene: |
METTL3, YTHDC1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes HCC cell proliferation, migration and invasion/metastasis; promotes tumor growth in vivo; inhibits apoptosis; facilitates cell cycle progression. |
| Molecular mechanism: |
m6A-modified hsa_circ_0058493 is methylated by METTL3; YTHDC1 binds hsa_circ_0058493 and promotes its nuclear export to the cytoplasm in an m6A-dependent manner, driving HCC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); m6A modification (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; MeRIP / MeRIP-seq; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Microarray |
| Clinical significance: |
High hsa_circ_0058493 expression is associated with worse prognosis/shorter survival and may be a prognostic marker/biomarker for HCC. |
| Description: |
hsa_circ_0058493 is up-regulated in HCC tissues and cells and acts as an oncogenic circRNA that promotes proliferation, cell-cycle progression, migration/invasion and tumor growth while inhibiting apoptosis. METTL3-mediated m6A modification enables YTHDC1 binding, which facilitates nuclear export of hsa_circ_0058493 to the cytoplasm and contributes to HCC progression; high expression predicts worse survival. |
| Confidence score: |
0.8814 |