circRNA basic information
circBase ID: hsa_circ_0006834
Name: hsa_circ_EPB41L5
Synonym: -
Host Gene: EPB41L5
Genomic location(hg19): chr2:120885263-120932576:+
Genomic location(hg38): chr2:120127687-120175000:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential prognostic biomarker for HCC; low expression is associated with vascular invasion, BCLC stage, shorter recurrence-free survival and shorter overall survival.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0006834 is an independent prognostic factor for HCC and predicts 2-year recurrence-free survival and overall survival; high expression is associated with higher recurrence-free survival and overall survival.
Description:

hsa_circ_0006834 is significantly down-regulated in HCC tissues compared with adjacent tissues. Its lower expression is associated with vascular invasion, BCLC stage, and worse recurrence-free and overall survival, supporting its role as a potential prognostic biomarker for HCC.
Confidence score:

0.7034
Other information
Title:

[Circular RNA hsa_circ_0006834 is a potential prognostic biomarker for hepatocellular carcinoma].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Published: 2023
PubMed ID: 38081601
Study type:

combined biological and clinical study
Data availability: Genome Sequencing Achieve database (GSA, https://hgdc.cncb.ac.cn/gsa); HRA000464
Code availability: -