| Expression pattern: |
UP |
| Associated gene: |
FGF5 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
promotes TNBC cell proliferation, migration, invasion, tube formation and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ_0041732 acts as a sponge of miR-149-5p and regulates FGF5 expression through miR-149-5p |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); angiogenesis (promotes); metastasis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0041732 had the potential as a therapeutic target for TNBC |
| Description: |
circ_0041732 is up-regulated in TNBC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, tube formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0041732 sponges miR-149-5p to increase FGF5 expression, forming a circ_0041732/miR-149-5p/FGF5 regulatory axis with potential therapeutic relevance in TNBC. |
| Confidence score: |
0.8175 |