| Expression pattern: |
UP |
| Associated gene: |
CEP85 |
| Associated microRNA: |
miR-326 |
| Biological function: |
Promotes glioblastoma cell viability, colony-forming ability, proliferation, migration, invasion, and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circRNA-SMO functions through a ceRNA mechanism by sponging miR-326, thereby upregulating CEP85 expression and promoting glioblastoma progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circRNA-SMO expression is associated with poor prognosis in glioblastoma patients; circRNA-SMO may be a potential therapeutic target. |
| Description: |
circRNA-SMO is upregulated in glioblastoma tissues and cell lines and high expression is associated with poor prognosis. Functionally, circRNA-SMO promotes glioblastoma proliferation, colony formation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-326, thereby increasing CEP85 expression. |
| Confidence score: |
0.722 |