| Expression pattern: |
UP |
| Associated gene: |
TRPV3, CCNB1, Ago2 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
Hsa_circ_0072765 promotes proliferation, cell cycle progression, activation and migration in TGF-beta1-induced hepatic stellate cells; knockdown inhibits these profibrotic cellular phenotypes. |
| Molecular mechanism: |
Hsa_circ_0072765 acts as a miR-197-3p sponge/decoy and upregulates TRPV3, thereby promoting TGF-beta1-induced HSC progression; exosomal hsa_circ_0072765 is also increased in TGF-beta1-treated LX2 cells. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); fibrosis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Cell Cycle Assay; Western Blot; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
This study found that hsa_circ_0072765 is up-regulated in a TGF-beta1-induced LX2 hepatic stellate cell model of liver fibrosis and in exosomes from these cells. Functionally, hsa_circ_0072765 promotes HSC proliferation, cell cycle progression, activation and migration. Mechanistically, it sponges miR-197-3p to increase TRPV3 expression, forming a hsa_circ_0072765/miR-197-3p/TRPV3 regulatory axis relevant to liver fibrosis. |
| Confidence score: |
0.7615 |