circRNA basic information
circBase ID: hsa_circ_0000144
Name: hsa_circ_SLAMF6
Synonym: -
Host Gene: SLAMF6
Genomic location(hg19): chr1:160472466-160472794:+
Genomic location(hg38): chr1:160502676-160503004:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer / BCa
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; adjacent normal tissues; non-tumor tissues; tumor tissues
Cell lines:

T24; EJ; UMUC3; RT4; 253J; SV-HUC-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RUNX2
Associated microRNA: miR-217
Biological function: hsa_circ_0000144 exerts oncogenic roles in bladder cancer; knockdown suppresses bladder cancer cell proliferation and invasion in vitro and reduces tumor growth in vivo.
Molecular mechanism: hsa_circ_0000144 acts as a competing endogenous RNA sponge for miR-217, attenuating miR-217-mediated suppression of RUNX2 and thereby facilitating RUNX2 expression.
Biological pathway or process:

proliferation (promotes); invasion (promotes); cell cycle (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model
Clinical significance:

High hsa_circ_0000144 expression was related with poor prognosis and could serve as a prognostic biomarker for bladder cancer patients.
Description:

hsa_circ_0000144 is up-regulated in bladder cancer tissues and cell lines, and high expression is associated with poor patient survival. Functionally, it promotes bladder cancer proliferation, invasion, cell-cycle progression, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-217 to increase RUNX2 expression.
Confidence score:

0.7631
Other information
Title:

Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression.

Journal: Gene
Published: 2018
PubMed ID: 30098434
Study type:

combined biological and clinical study
Data availability: GSE92675
Code availability: -