| Expression pattern: |
UP |
| Associated gene: |
HMG20A |
| Associated microRNA: |
miR-670-3p |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion/metastasis and tumor growth; circABCB10 silencing inhibits these malignant phenotypes. |
| Molecular mechanism: |
circABCB10 functions as a ceRNA/miRNA sponge for miR-670-3p, thereby increasing HMG20A expression; miR-670-3p overexpression or HMG20A knockdown reverses circABCB10 oncogenic effects. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; CCK8; BrdU; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Transfection; In Vivo Animal Model; Western Blot; Survival Analysis |
| Clinical significance: |
High circABCB10 expression is associated with lower overall survival in HCC patients and predicts poor clinical outcomes. |
| Description: |
circABCB10 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation and migration/invasion by sponging miR-670-3p to increase HMG20A expression, and its high expression is associated with poor overall survival. |
| Confidence score: |
0.7661 |