| Expression pattern: |
UP |
| Associated gene: |
PI3K, AKT, JNK, c-Jun, MMP-2, MMP-9, caspase-3, caspase-9 |
| Associated microRNA: |
miR-145 |
| Biological function: |
Promotes gastric cancer cell growth and migration; inhibits apoptosis. |
| Molecular mechanism: |
circMAN2B2 negatively regulates miR-145; circMAN2B2 knockdown deactivates PI3K/AKT and activates JNK via miR-145. |
| Biological pathway or process: |
PI3K/AKT (promotes); JAK/STAT (inhibits); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
CircMAN2B2 was highly expressed in GC tissues compared with paracancerous tissues, suggesting it may serve as a biomarker/therapeutic target. |
| Description: |
circMAN2B2 is up-regulated in gastric carcinoma tissues and acts as an oncogenic circRNA. Its knockdown suppresses proliferation/survival and migration and promotes apoptosis in SNU-16 and AGS cells, partly by relieving negative regulation on miR-145 and modulating PI3K/AKT and JNK signaling. |
| Confidence score: |
0.5434 |