| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
miR-181b-5p |
| Biological function: |
CircEZH2 promotes glioma cell proliferation, colony formation, migration, invasion and tumor growth, antagonizes lidocaine-mediated inhibition, and suppresses glioma cell differentiation. |
| Molecular mechanism: |
CircEZH2 acts as a sponge for miR-181b-5p and mediates the lidocaine-associated circEZH2/miR-181b-5p regulatory pathway in glioma. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); other pathway/process (inhibits); drug resistance (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circEZH2 expression was increased with the grade of glioma deterioration. |
| Description: |
circEZH2 is up-regulated in glioma tissues and cells and its expression increases with glioma grade. Functionally, circEZH2 promotes malignant glioma behaviors and antagonizes lidocaine-mediated inhibition of proliferation, migration, invasion and tumor growth. Mechanistically, circEZH2 sponges miR-181b-5p as part of the circEZH2/miR-181b-5p regulatory pathway. |
| Confidence score: |
0.7045 |