circRNA basic information
circBase ID: -
Name: hsa_circ_MBOAT2
Synonym: circMBOAT2
Host Gene: MBOAT2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005045
MONDO name: hypertrophic cardiomyopathy
Disease details: hypertrophic cardiomyopathy
Disease DO ID:
 11984
Disease MeSH ID:
 D002312
Disease NCIt ID:
 C34449
Disease ICD11 ID:
 1830681485
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Circulating biomarker candidate for distinguishing HCM (including HNCM/HOCM) from controls.
Molecular mechanism: Not specified.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Circulating circMBOAT2 distinguishes HCM/HNCM/HOCM patients from controls with reported ROC discrimination (AUC range for circRNAs).
Description:

Serum circMBOAT2 is down-regulated in HCM and provides diagnostic discrimination between HCM (including HNCM/HOCM) and controls based on ROC analyses, supporting its potential as a blood-based biomarker.
Confidence score:

0.459
Other information
Title:

Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy.

Journal: Scientific reports
Published: 2019
PubMed ID: 31889077
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article and its Supplementary Information files.
Code availability: www.r-project.org